Heilongjiang Medicine is reported below. 1 Materials and Methods 1.1 * General data -06 ~ 2011-10, 110 patients with bronchial asthma, all cases met the diagnostic criteria of the Chinese Medical Association Respiratory Branch 2003 bronchial asthma prevention guidelines, and exclude cardiac asthma, of which: There were 52 males and 58 females. The age ranged from 18 to 86 years old, with an average age of 52 years. There were 72 cases of moderate asthma and 38 cases of severe asthma. They were randomly divided into treatment group and control group. There was no significant difference in gender, age and clinical manifestation between the two groups, P>0.05, which was comparable. 1.2 Methods The control group was treated with oxygen, infusion, adrenal cortex hormone, aminophylline and other conventional treatments. The treatment group was treated with a new type of compressed air-powered atomized inhaler on the above basis. Add: 1 budesonide 2.0 mL + ipratropium 2.0mL + normal saline 2.0mL, nebulized inhalation: 4 ~ 8h1 times; 2 salbutamol atomized solution 2.0mL + normal saline 2. 0mL, nebulized inhalation: 4 times, 1 and 2 two kinds of atomized liquid Alternate use, the interval between the two uses at least 1h. 1.3 Clinical criteria for efficacy judgment: asthma symptoms were completely relieved, and lung wheezing sounds basically disappeared. Significantly effective: asthma symptoms were significantly less than before treatment, lung wheezing was significantly reduced; effective: asthma symptoms were alleviated, lung wheezing remained left; invalid: clinical asthma symptoms and wheezing sounds were not significantly improved. And total efficiency = clinical control + markedly effective + effective. 1.4 Statistical methods 0 Statistical analysis was performed. The t-test was used for comparison between groups. P<0.05 was considered as significant and statistically significant. 2 Results After clinical observation and comparison, the total effective rate was 98.2% in the treatment group and 76.4% in the control group. The total effective rate of the two treatment methods was compared by statistical analysis and analysis using the t test, P< 0.05, the difference was significant, the treatment group was superior to the control group, and the statistical significance was compared. The comparison between the two groups was shown in Table 1. Table 1 Comparison of the total effective rate between the treatment group and the control group The number of cases was clinically effective and effective. Efficiency (%) Treatment group 3 Discussion Bronchial asthma is the most common respiratory emergency disease in the clinic. If the treatment is not in place, asthma is persistent and life-threatening. * Most of them occur in middle-aged and elderly people, and the incidence of children is also on the rise. Frequent exposure to cold air, cold food, physical and chemical factors, upper and lower respiratory tract infections can induce aggravation, and repeated attacks, if not treated, can be converted to COPD, pulmonary heart disease, resulting in poor prognosis, quality of life, The mechanism of occurrence is mainly related to airway hyperresponsiveness. 12. Budesonide is an inhaled glucocorticoid. The main mechanism of action is to inhibit the migration and activation of inflammatory cells, inhibit the release of inflammatory mediators, and enhance the response of smooth muscle cell receptors. Sex. Ipratropium bromide is a cholinergic receptor antagonist, which can reduce the vagal excitability and relax the bronchial function, and has the effect of reducing the secretion of sputum. It has synergistic effect with the inhalation of P2 receptor agonist, especially For patients with nocturnal asthma and multiple sputum 4. Salbutamol is a P2 receptor agonist, the mechanism of action is the receptor of the stimulating respiratory tract, activates adenylate cyclase to make intracellular cyclic adenosine monophosphate (cAMp) content Increased, free Ca 2+ reduced, thereby relaxing bronchial smooth muscle, is the drug of choice for the control of acute asthma attack. Currently, mild asthma is recommended for inhalation therapy, while moderate to severe is recommended for inhalation therapy + intravenous therapy to effectively control asthma attacks. . The above three drugs combined with inhalation, so that the drug directly reaches the respiratory tract, can quickly alleviate asthma symptoms. Therefore, in the conventional application of anti-inflammatory anti-inflammatory drugs, combined with budesonide, ipratropium bromide and salbutamol in a compressed air atomized inhalation, can effectively alleviate the acute attack of asthma, improve the quality of life of patients, improve lungs Function, method is simple and easy to implement, it is worthy of clinical promotion.
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